Cleanroom Passbox | Static vs Dynamic Cleanroom Pass Boxes

Nowadays, maintaining strict contamination control is a constant challenge in cleanroom environments across industries like pharmaceuticals, biotechnology, semiconductors, food processing and laboratories. One of the necessaryl solution is the cleanroom pass box also known as a pass through chamber which allows for the safe transfer of materials without compromising the sterile atmosphere.

In this blog, we will break down the two main types of pass boxes: static pass boxes and dynamic pass boxes. Their key specifications, differences, applications, validation procedures, industry standards and what to look for in a GMP certified pass box supplier. We will also address commonly searched queries such as:

• Dynamic pass box with HEPA filter price
• GMP certified static pass box supplier
• And more essential buying and compliance considerations

Whether it is about designing a new cleanroom or upgrading existing setup this guide will help to make an informed, compliant and cost effective decision.

What is a Pass Box and Why is it Imperial in Cleanrooms?

A cleanroom pass box also known as a pass through box or pass through chamber is a important piece of equipment used in contamination control. It is an enclosed cabinet with two interlocked doors on opposite sides which is designed to transfer materials, samples or equipment between cleanrooms  to a non clean area without compromising air cleanliness.

The advanced door interlocking system makes certain that only one door opens at a time. This prevents cross contamination and maintains cleanroom pressure levels and reduces the risk of airborne particles entering the controlled environment.

Using a pass box in cleanrooms not only ensures safety but efficient material transfer that helps industries comply with GMP that stands for Good Manufacturing Practices and ISO cleanroom standards. These pass through chambers have variety of uses in pharmaceuticals, biotechnology, semiconductor manufacturing and food processing where strict contamination control is essential for product quality and safety.

In essence, a cleanroom pass through box is not just convenient; it is essential for preserving cleanroom integrity and supporting smooth also contamination free operations.

Types of Pass Boxes

Static Pass Box

• Definition: Used typically for transferring materials between cleanrooms of the same cleanliness classification.
• Key Features:
  • Stainless steel construction commonly SUS304.
  • Mechanical or electronic interlocking doors.
  • No air filtration system or blower.
  • UV lamp for microbial control.
• Applications: Suitable for static pass box for food processing industry, low risk cleanroom zones and general pharmaceutical manufacturing.
• Suppliers: There are multiple GMP certified static pass box suppliers who specialize in producing boxes that meet pharma and food industry standards.

Dynamic Pass Box

• Definition: Designed to transfer materials between different clean zones including from non classified to classified cleanrooms.
• Key Features:
  • Built in HEPA filtration with H13 or H14 filters.
  • Motor blower for continuous airflow and creating an air shower effect.
  • Differential pressure gauge to monitor filter integrity.
  • Advanced electronic interlocking system.
  • UV light disinfection.
• Applications: Used extensively in pharmaceutical dynamic pass box specifications environments, semiconductor fabs and aseptic processing.
• Variants: Some are customized to include dynamic pass box with air shower system for enhanced contamination control.
• Price: Dynamic pass boxes tend to be on the higher side in price due to their complex systems involving fans, filters and sensors. For dynamic pass box with HEPA filter prices expect prices to vary significantly based on size and customization

Technical and Design Specifications of Cleanroom Pass Boxes

Pass boxes are available in two main types : Static Pass Box and Dynamic Pass Box. Both are designed to maintain cleanroom integrity but they differ in terms of airflow, filtration and applications. Below are the detailed specifications:

Specification	Static Pass box	Dynamic pass box
Material	Stainless steel SUS304	Stainless Steel SUS304 or SUS316L
Door Type	Mechanical or electronic interlocking	Electronic interlock with advanced safety controls
HEPA/ULPA Filter	Not available	H13/H14 ULPA filter with 99.99% efficiency
Airflow	No Airflow system	Continuous laminar airflow (~0.45 m/s) with air shower system
UV Lamp Wattage	~8W for basic disinfection	~18W for enhanced sterilization
Pressuring Monitoring	Not included	Equipped with differential pressure gauge
Power Supply	220V/50Hz	220V / 50Hz
Typical Dimensions	500x500x500 mm to 800x800x800 mm	500×500×500 mm to 800×800×800 mm
Compliance	Available from GMP certified suppliers	GMP and ISO certified, CE marked manufacturers
Application Areas	Food processing, research labs and non critical pharma	Sterile pharmaceutical cleanrooms, semiconductor fabs and aseptic zones

Key points for Cleanroom Pass Boxes:

• Static Pass Boxes are ideal for transferring materials in less critical areas where airflow and filtration are not mandatory.
• Dynamic Pass Boxes are designed for high level contamination control with HEPA/ULPA filters, airflow systems and strict GMP/ISO compliance which makes them suitable for sterile and aseptic cleanroom applications.

Key Features of Cleanroom Pass Through Chamber Interlocking Doors

Interlocking doors in pass boxes are critical for preventing cross contamination and pressure loss. Features include:

• Mechanical or electronic interlock to ensure one door closes before the opposite opens.
• Visual indicator lights for door status.
• Integration with cleanroom monitoring systems.
• Safety lockouts for emergency protocols.

Such systems are obligatory for interlocking pass box for GMP facility compliance and are included in installation standards.

Validation and Maintenance of Cleanroom Pass Boxes

How to Validate a Cleanroom Pass Box

• Verify door interlock mechanisms function correctly to avoid simultaneous door opening.
• Test UV lamp functionality and replace after about 4000 hours.
• For dynamic pass boxes, perform HEPA filter integrity tests (DOP/PAO testing).
• Check differential pressure gauge readings regularly.
• Conduct particle count and microbiological sampling inside the box.
• Review documentation and certification compliance according to GMP and ISO standards.

Maintenance Checklist of Cleanroom Passbox

• Routine cleaning of the chamber interior and exterior.
• Scheduled UV lamp and HEPA filter replacement.
• Lubrication and inspection of door locking mechanisms.
• Calibration of sensors and gauges.
• Documentation of maintenance activities for audits.

Industry Specific Applications for Cleanroom Pass Box

• Pharmaceuticals: Multiple suppliers provide pharmaceutical dynamic pass box specifications customised to FDA and EMA regulations.
• Semiconductor Industry: Specialized semiconductor pass through chamber manufacturers offer ultra clean transfer boxes meeting ISO 3 to 5 class cleanroom standards.
• Food Industry: Static pass boxes adapted for the food processing industry ensure hygiene with simplified design.
• Research Labs: Material transfer hatches for research labs are available with variable costs depending on customization and certification.
• Europe: CE marked pass through box manufacturers in Europe focus on advanced safety and compatibility with EU regulations.

Buying Guide and Custom Designs of Static & Dynamic Pass Box

• Assess your cleanroom classification and contamination risk.
• Choose between static or dynamic pass boxes accordingly.
• Seek custom cleanroom pass box design specifications for unique applications.
• Consider integrating additional features such as air showers or electronic monitoring.
• Contact pass box manufacturers for quotes including pass box price and after sale support.
• Check for certifications like GMP, ISO  and CE for quality assurance.
• Look for suppliers offering installation support and detailed static pass box installation guide PDF for seamless setup.

Conclusion: Choosing the Right Pass Box for Cleanrooms

Whether you choose a Static Pass Box for low risk environments or a Dynamic Pass Box with HEPA/ULPA filtration for high contamination control, investing in the right cleanroom pass through box is vital for maintaining operational efficiency and meeting regulatory standards.

By carefully evaluating specifications, pricing and maintenance requirements, industries can ensure contamination free transfer of materials, support compliance with GMP and ISO cleanroom guidelines and enhance the overall reliability of their cleanroom operations.

In short, the right pass box is not just equipment In fact its an essential safeguard for product quality, safety and cleanroom integrity.